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3 Neuroprotective plant extracts in preclinical anti-PD effects 3.1 Antioxidant stress The central nervous system is particularly susceptible to oxidative stress due to its high metabolic activity and oxygen demands ( Neuroprotective plant extracts possess potent antioxidant and free radical scavenging properties, with their mechanisms likely linked to the activation of the Nrf2 signaling pathway and modulation of ROS production within mitochondria

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